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  • 1
    Publication Date: 2019
    Description: 〈p〉Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external signals indicating the risk involved in eating within a particular environment. The behaviors driven by the former are manifestations of hunger, and the latter, anxiety. The connection between pathologic anxiety and reduced eating in conditions like typical depression and anorexia is well known. Conversely, anti-anxiety drugs such as benzodiazepines increase appetite. Here, we show that GABAergic neurons in the diagonal band of Broca (DBB〈sup〉GABA〈/sup〉) are responsive to indications of risk and receive monosynaptic inhibitory input from lateral hypothalamus GABAergic neurons (LH〈sup〉GABA〈/sup〉). Activation of this circuit reduces anxiety and causes indiscriminate feeding. We also found that diazepam rapidly reduces DBB〈sup〉GABA〈/sup〉 activity while inducing indiscriminate feeding. Our study reveals that the LH〈sup〉GABA〈/sup〉-〉DBB〈sup〉GABA〈/sup〉 neurocircuit overrides anxiogenic environmental cues to allow feeding and that this pathway may underlie the link between eating and anxiety-related disorders.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 2
    Publication Date: 2016-06-21
    Description: Oriented inclusions of clinopyroxene, orthopyroxene, sodic amphibole and rutile have been identified in garnet from the Lüliangshan garnet peridotite massif in the North Qaidam ultrahigh-pressure metamorphic (UHPM) belt, northern Tibetan Plateau, NW China. Electron backscatter diffraction (EBSD) analyses demonstrate that nearly half of the measured intracrystalline clinopyroxene (8 out of 17) have topotactic crystallographic relationships with host garnet, i.e., (100) Cpx //{112} Grt , (010) Cpx //{110} Grt and [001] Cpx //〈111〉 Grt . One fifth of the oriented sodic amphibole (23 out of 110) inclusions of have topotactic crystallographic relationships with host garnet, i.e., (010) Amp //{112} Grt , (100) Amp //{110} Grt and [001] Amp //〈111〉 Grt . Over a third of rutile (36 out of 99) inclusions also show a close crystallographic orientation relationship with host garnet in that one 〈103〉 Rt and one 〈110〉 Rt parallel to two 〈111〉 Grt while the axes of [001] Rt exhibit small girdles centred the axes of 〈111〉 Grt . But, no “well-fit” crystallographic relationship was observed between orthopyroxene inclusions and host garnet. Considering a very long and complex history for the Lüliangshan garnet peridotite, we suggest that the low fit rates for these oriented minerals may result from several possible assumptions including different generations or multi-stage formation mechanisms, heterogeneous nucleation and growth under non-equilibrium conditions, and partial changes of initial crystallographic orientations of some inclusions. However, the residual quantitative “well-fit” crystallographic information is sufficient to indicate that the nucleation and growth of many pyroxene, amphibole and rutile are controlled by the lattice of the host garnet. The revealed close topotactic relationships accompanied by clear shape orientations provide quantitative microstructural evidence demonstrating a most likely exsolution/precipitate origin for at least some of the oriented phases of pyroxene, sodic amphibole and rutile from former majoritic garnet and support an ultra-deep (〉180 km depth) origin of the Lüliangshan garnet massif. This article is protected by copyright. All rights reserved.
    Print ISSN: 0263-4929
    Electronic ISSN: 1525-1314
    Topics: Geosciences
    Published by Wiley
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  • 3
    Publication Date: 2018
    Description: 〈p〉Paired measurements of 〈sup〉14〈/sup〉C/〈sup〉12〈/sup〉C and 〈sup〉230〈/sup〉Th ages from two Hulu Cave stalagmites complete a precise record of atmospheric 〈sup〉14〈/sup〉C covering the full range of the 〈sup〉14〈/sup〉C dating method (~54,000 years). Over the last glacial period, atmospheric 〈sup〉14〈/sup〉C/〈sup〉12〈/sup〉C ranges from values similar to modern values to values 1.70 times higher (42,000 to 39,000 years ago). The latter correspond to 〈sup〉14〈/sup〉C ages 5200 years less than calibrated ages and correlate with the Laschamp geomagnetic excursion followed by Heinrich Stadial 4. Millennial-scale variations are largely attributable to Earth’s magnetic field changes and in part to climate-related changes in the oceanic carbon cycle. A progressive shift to lower 〈sup〉14〈/sup〉C/〈sup〉12〈/sup〉C values between 25,000 and 11,000 years ago is likely related, in part, to progressively increasing ocean ventilation rates.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2019
    Description: 〈p〉Tetrahexahedral particles (~10 to ~500 nanometers) composed of platinum (Pt), palladium, rhodium, nickel, and cobalt, as well as a library of bimetallic compositions, were synthesized on silicon wafers and on catalytic supports by a ligand-free, solid-state reaction that used trace elements [antimony (Sb), bismuth (Bi), lead, or tellurium] to stabilize high-index facets. Both simulation and experiment confirmed that this method stabilized the {210} planes. A study of the PtSb system showed that the tetrahexahedron shape resulted from the evaporative removal of Sb from the initial alloy—a shape-regulating process fundamentally different from solution-phase, ligand-dependent processes. The current density at a fixed potential for the electro-oxidation of formic acid with a commercial Pt/carbon catalyst increased by a factor of 20 after transformation with Bi into tetrahexahedral particles.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2016-02-21
    Description: Control over surface plasmons (SPs) is essential in a variety of cutting-edge applications, such as highly integrated photonic signal processing systems, deep-subwavelength lasing, high-resolution imaging, and ultrasensitive biomedical detection. Recently, asymmetric excitation of SPs has attracted enormous interest. In free space, the analog of electromagnetically induced transparency (EIT) in metamaterials has been widely investigated to uniquely manipulate the electromagnetic waves. In the near field, we show that the dark mode coupling mechanism of the classical EIT effect enables an exotic and straightforward excitation of SPs in a metasurface system. This leads to not only resonant excitation of asymmetric SPs but also controllable exotic SP focusing by the use of the Huygens-Fresnel principle. Our experimental findings manifest the potential of developing plasmonic metadevices with unique functionalities.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2019
    Description: Abstract Using dynamic compression technique, the equation of state (EOS) for Fe‐ 8.6 wt% Si was measured up to 240 GPa and 4670 K. A least square fit to the experimental data yields the Hugoniot parameters C0=4.603±0.101 km/s and λ=1.505±0.037 with initial density ρ0=7.386±0.021 g/cm3. Based on the Hugoniot data, the calculated isothermal equation of state is consistent with static compression data when the lattice Grüneisen parameter γl =1.65(7.578/ρ) and electronic Grüneisen parameter γe=1.83. The calculated pressure‐density data at 300 K were fitted to a third order Birch‐Murnaghan EOS with zero‐pressure the parameters: K0=192.1±6.3 GPa, =4.71±0.27 with fixed ρ0ε =7.578±0.050 g/cm3. Under the conditions of Earth's core, the densities of Fe‐8.6±2.0 wt% Si and Fe‐3.8±2.9 wt% Si agree with PREM data of the outer and the inner core, respectively. These are the upper limits for Si in the core assuming Si is the only light element. Simultaneously considering the geophysical and geochemical constraints for a Si‐S‐bearing core, the outer core may contain 3.8±2.9 wt % Si and 5.6±3.0 wt % S.
    Print ISSN: 2169-9313
    Electronic ISSN: 2169-9356
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
    Publication Date: 2019
    Description: 〈p〉Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence–binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was suppressed in ATMs of diet-induced obese mice and was correlated with adipose tissue inflammation. Loss of SBP2 initiated metabolic activation of ATMs, inducing intracellular reactive oxygen species content and inflammasome, which subsequently promoted IL-1β–associated local proliferation and infiltration of proinflammatory macrophages. ATM-specific knockdown of SBP2 in obese mice promoted insulin resistance by increasing fat tissue inflammation and expansion. Reexpression of SBP2 improved insulin sensitivity. Last, an herbal formula that specifically induced SBP2 expression in ATMs can experimentally improve insulin sensitivity. Clinical observation revealed that it improved hyperglycemia in patients with diabetes. This study identified SBP2 in ATMs as a potential target in rescuing insulin resistance in obesity.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 9
    Publication Date: 2019
    Description: 〈p〉Infrequent extreme events such as large earthquakes pose hazards and have lasting impacts on landscapes and biogeochemical cycles. Sediments provide valuable records of past events, but unambiguously identifying event deposits is challenging because of nonlinear sediment transport processes and poor age control. Here, we have been able to directly track the propagation of a tectonic signal into stratigraphy using reservoir sediments from before and after the 2008 Wenchuan earthquake. Cycles in magnetic susceptibility allow us to define a precise annual chronology and identify the timing and nature of the earthquake’s sedimentary record. The grain size and Rb/Sr ratio of the sediments responded immediately to the earthquake. However, the changes were muted until 2 years after the event, when intense monsoonal runoff drove accumulation of coarser grains and lower Rb/Sr sediments. The delayed response provides insight into how climatic and tectonic agents interact to control sediment transfer and depositional processes.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 10
    Publication Date: 2019
    Description: 〈p〉The interplay of magnetism and topology is a key research subject in condensed matter physics, which offers great opportunities to explore emerging new physics, such as the quantum anomalous Hall (QAH) effect, axion electrodynamics, and Majorana fermions. However, these exotic physical effects have rarely been realized experimentally because of the lack of suitable working materials. Here, we predict a series of van der Waals layered MnBi〈sub〉2〈/sub〉Te〈sub〉4〈/sub〉-related materials that show intralayer ferromagnetic and interlayer antiferromagnetic exchange interactions. We find extremely rich topological quantum states with outstanding characteristics in MnBi〈sub〉2〈/sub〉Te〈sub〉4〈/sub〉, including an antiferromagnetic topological insulator with the long-sought topological axion states on the surface, a type II magnetic Weyl semimetal with one pair of Weyl points, as well as a collection of intrinsic axion insulators and QAH insulators in even- and odd-layer films, respectively. These notable predictions, if proven experimentally, could profoundly change future research and technology of topological quantum physics.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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