Publication Date:
2015-07-23
Description:
Article The inhibition of bacterial glycosyltransferase has the potential to be an effective therapeutic target against drug resistance bacteria. Here, the authors present a novel class of inhibitor compounds based on a monosaccharide scaffold, which are able to eliminate bacterial infections in mice. Nature Communications doi: 10.1038/ncomms8719 Authors: Johannes Zuegg, Craig Muldoon, George Adamson, Declan McKeveney, Giang Le Thanh, Rajaratnam Premraj, Bernd Becker, Mu Cheng, Alysha G. Elliott, Johnny X. Huang, Mark S. Butler, Megha Bajaj, Joachim Seifert, Latika Singh, Nicola F. Galley, David I. Roper, Adrian J. Lloyd, Christopher G. Dowson, Ting-Jen Cheng, Wei-Chieh Cheng, Dieter Demon, Evelyne Meyer, Wim Meutermans, Matthew A. Cooper
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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