Publication Date:
1989-06-02
Description:
Cytotoxic T lymphocytes (CTLs) recognize foreign antigens, including viral proteins, in association with major histocompatibility complex (MHC) class I molecules. Brefeldin A, a specific inhibitor of exocytosis, completely and reversibly inhibited the presentation of viral proteins, but not exogenous peptides, to MHC class I-restricted CTLs directed against influenza virus antigens. The effect of brefeldin A on antigen presentation correlated with its inhibition of intracellular transport of newly synthesized class I molecules. Brefeldin A is thus a specific inhibitor of antigen processing for class I-restricted T cell recognition. Its effect on antigen presentation supports the idea that exogenous peptide antigens associate with cell surface class I molecules, whereas protein antigens processed via the cytosolic route associate with nascent class I molecules before they leave the trans-Golgi complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yewdell, J W -- Bennink, J R -- New York, N.Y. -- Science. 1989 Jun 2;244(4908):1072-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Viral Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2471266" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*drug effects/immunology
;
Antigens, Viral/*immunology
;
Biological Transport/drug effects
;
Brefeldin A
;
Cell Membrane/immunology
;
Cyclopentanes/*pharmacology
;
Endoplasmic Reticulum/immunology
;
Epitopes/immunology
;
Exocytosis/drug effects
;
Golgi Apparatus/immunology
;
H-2 Antigens/immunology
;
Hemagglutinins/genetics/immunology
;
Histocompatibility Antigens Class I/immunology
;
Mice
;
Nucleoproteins/immunology
;
Orthomyxoviridae/immunology
;
T-Lymphocytes, Cytotoxic/drug effects/*immunology
;
Transfection
;
Viral Proteins/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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