Publication Date:
2003-07-12
Description:
Choosing an action that leads to a desired goal requires an understanding of the linkages between actions and their outcomes. We investigated neural mechanisms of such goal-based action selection. We trained monkeys on a task in which the relation between visual cues, action types, and reward conditions changed regularly, such that the monkeys selected their actions based on anticipated reward conditions. A significant number of neurons in the medial prefrontal cortex were activated, after cue presentation and before motor execution, only by particular action-reward combinations. This prefrontal activity is likely to underlie goal-based action selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsumoto, Kenji -- Suzuki, Wataru -- Tanaka, Keiji -- New York, N.Y. -- Science. 2003 Jul 11;301(5630):229-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. matsumot@postman.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855813" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Analysis of Variance
;
Animals
;
Brain Mapping
;
Conditioning (Psychology)
;
Cues
;
Decision Making
;
*Goals
;
Haplorhini
;
*Learning
;
Memory/physiology
;
Neurons/*physiology
;
Prefrontal Cortex/*physiology
;
Psychomotor Performance
;
*Reward
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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