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  • 2020-2022  (433)
  • 1995-1999  (642)
  • 1945-1949  (12)
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  • 1
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    Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-31
    Description: BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts in vitro and in vivo with hRad50, which forms a complex with hMre11 and p95/nibrin. Upon irradiation, BRCA1 was detected in discrete foci in the nucleus, which colocalize with hRad50. Formation of irradiation-induced foci positive for BRCA1, hRad50, hMre11, or p95 was dramatically reduced in HCC/1937 breast cancer cells carrying a homozygous mutation in BRCA1 but was restored by transfection of wild-type BRCA1. Ectopic expression of wild-type, but not mutated, BRCA1 in these cells rendered them less sensitive to the DNA damage agent, methyl methanesulfonate. These data suggest that BRCA1 is important for the cellular responses to DNA damage that are mediated by the hRad50-hMre11-p95 complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhong, Q -- Chen, C F -- Li, S -- Chen, Y -- Wang, C C -- Xiao, J -- Chen, P L -- Sharp, Z D -- Lee, W H -- CA 30195/CA/NCI NIH HHS/ -- CA 58183/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):747-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10426999" target="_blank"〉PubMed〈/a〉
    Keywords: BRCA1 Protein/*metabolism ; Cell Cycle Proteins/*metabolism ; Cell Nucleus/*metabolism ; Cell Survival ; *DNA Damage ; *DNA Repair Enzymes ; DNA-Binding Proteins/*metabolism ; Gamma Rays ; Genes, BRCA1 ; Humans ; Methyl Methanesulfonate/pharmacology ; Mutagens/pharmacology ; Mutation ; *Nuclear Proteins ; Rad51 Recombinase ; Recombination, Genetic ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    DNA topoisomerase IIbeta and neural development (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-30
    Description: DNA topoisomerase IIbeta is shown to have an unsuspected and critical role in neural development. Neurogenesis was normal in IIbeta mutant mice, but motor axons failed to contact skeletal muscles, and sensory axons failed to enter the spinal cord. Despite an absence of innervation, clusters of acetylcholine receptors were concentrated in the central region of skeletal muscles, thereby revealing patterning mechanisms that are autonomous to skeletal muscle. The defects in motor axon growth in IIbeta mutant mice resulted in a breathing impairment and death of the pups shortly after birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, X -- Li, W -- Prescott, E D -- Burden, S J -- Wang, J C -- NS10537/NS/NINDS NIH HHS/ -- NS27963/NS/NINDS NIH HHS/ -- NS36193/NS/NINDS NIH HHS/ -- R01 NS036193/NS/NINDS NIH HHS/ -- R01 NS036193-02/NS/NINDS NIH HHS/ -- R01 NS041311/NS/NINDS NIH HHS/ -- R01 NS041311-03/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Jan 7;287(5450):131-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Skirball Institute of Molecular Medicine, New York University Medical School, 540 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10615047" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology/ultrastructure ; Cell Lineage ; Cues ; DNA Repair ; DNA Topoisomerases, Type II/genetics/*metabolism ; DNA-Binding Proteins ; Diaphragm/chemistry/embryology/innervation ; Embryonic and Fetal Development ; Gene Targeting ; Intercostal Muscles/innervation ; Mice ; Mice, Knockout ; Motor Neurons/physiology/ultrastructure ; Muscle, Skeletal/embryology/*innervation ; Neuromuscular Junction/*embryology/growth & development ; Neurons, Afferent/physiology/ultrastructure ; Presynaptic Terminals/ultrastructure ; Receptors, Cholinergic/analysis ; Skin/innervation ; Spinal Cord/embryology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-04-21
    Description: Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, C J -- Friedman, D J -- Wang, C -- Metelev, V -- Pardee, A B -- AI-35511/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):429-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716549" target="_blank"〉PubMed〈/a〉
    Keywords: *Apoptosis ; Base Sequence ; *CDC2-CDC28 Kinases ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinases/metabolism ; Enzyme Activation ; Gene Products, tat/pharmacology/*physiology ; Genes, tat ; *Hiv-1 ; Humans ; Leukocytes, Mononuclear/*cytology/enzymology ; Molecular Sequence Data ; Protein-Serine-Threonine Kinases/metabolism ; Recombinant Proteins/pharmacology ; T-Lymphocytes/*cytology/enzymology ; Transfection ; Tumor Cells, Cultured ; tat Gene Products, Human Immunodeficiency Virus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Atomic-scale desorption through electronic and vibrational excitation mechanisms (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-06-16
    Description: The scanning tunneling microscope has been used to desorb hydrogen from hydrogen-terminated silicon (100) surfaces. As a result of control of the dose of incident electrons, a countable number of desorption sites can be created and the yield and cross section are thereby obtained. Two distinct desorption mechanisms are observed: (i) direct electronic excitation of the Si-H bond by field-emitted electrons and (ii) an atomic resolution mechanism that involves multiple-vibrational excitation by tunneling electrons at low applied voltages. This vibrational heating effect offers significant potential for controlling surface reactions involving adsorbed individual atoms and molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, T C -- Wang, C -- Abeln, G C -- Tucker, J R -- Lyding, J W -- Avouris, P -- Walkup, R E -- New York, N.Y. -- Science. 1995 Jun 16;268(5217):1590-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17754609" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Abstract: Steep and Gentle Slope Depositional Systems in Lacustrine Rift Basins - A Case study of the Huagou Sag in the Bohai Bay Basin: Facies Composition and Geological Controls  (1999)
    American Association of Petroleum Geologists
    Details
    Publication Date: 1999-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by American Association of Petroleum Geologists
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  • 6
    Electronic Resource
    Electronic Resource
    Onset of convection in a fluid-saturated rectangular box, bottom heated by constant flux (1999)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 11 (1999), S. 1673-1675 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Thermoconvective instability of a rectangular box containing a fluid-saturated porous media is studied. The box top is maintained at constant temperature and the bottom is heated by constant flux. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.870027
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Alfvén resonance on low-frequency fast wave current drive (1995)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 2760-2764 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Alfvén resonances may occur on the low- and high-field sides for a low-frequency fast wave current drive scenario proposed for the International Thermonuclear Experimental Reactor (ITER) [Nucl. Fusion 31, 1135 (1991)]. At the resonance on the low-field side, the fast wave may be mode converted into a short-wavelength slow wave, which can be absorbed by electrons at the plasma edge, before the fast wave propagates into the core area of the plasma. Such absorption may cause a significant parasitic power loss. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.871241
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  • 8
    Electronic Resource
    Electronic Resource
    On spurious modes for finite Larmor radius models in the ion cyclotron range of frequencies (1995)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 2863-2865 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Spurious resonances exist in the dispersion relations for finite Larmor radius models in plasma heating in the ion cyclotron range of frequencies. The spurious resonances occur when the highest-order coefficient in a fourth-order equation vanishes. It is shown that the spurious resonances cannot be removed by using a sixth-order equation because the highest-order coefficient in the sixth-order equation also vanishes at the same location as the highest-order coefficient in the fourth-order equation. However, the spurious modes are often not excited when solving the corresponding ordinary differential equations (ODEs) for an incident fast wave so that the solutions from the ODEs are often accurate. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.871185
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  • 9
    Electronic Resource
    Electronic Resource
    Parallel forces induced by waves in ion cyclotron range of frequencies (1995)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 1056-1062 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new mechanism is identified for radio frequency (RF) wave induced force and current drive caused by a kinetic flux carried by coherent oscillations of plasma particles. The induced force along a magnetic field line by RF heating of plasmas is calculated with a one-dimensional slab model, and found to be contributed by the plasma power absorption and spatial inhomogeneity. The inhomogeneity term consists of a kinetic flux and a flux related to RF wave helicity injection rate. The effect from the kinetic flux exists only in a warm plasma, whereas, in contrast, the effect from the helicity related flux exists even in a cold plasma. The forces are calculated for both electrons and ions in the ion cyclotron range of frequencies (ICRF), and the effects from the ion cyclotron and the second harmonic resonance are included. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.871384
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  • 10
    Electronic Resource
    Electronic Resource
    Influence of imperfections on the dynamical response in model quantum cellular automata (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 6571-6576 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The time-dependent behavior of quantum cellular automata (QCA) with imperfections is examined. We have studied a chain of quantum cells with the imperfections introduced by (i) variations of intercellular distances, (ii) variations of intercell tunneling strengths, and (iii) stray charges. We find that imperfections like these may easily impair the switching properties of semiconductor based QCAs. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370163
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