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  • Articles  (3)
  • Science. 244(4905): 692-4.  (1)
  • Science. 299(5605): 363. doi: 10.1126/science.1077838.  (1)
  • Science. 322(5905): 1247-50. doi: 10.1126/science.1164594.  (1)
  • 25
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  • Articles  (3)
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  • 1
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    Insulin staining of ES cell progeny from insulin uptake (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, Jayaraj -- Anderson, William J -- Kume, Shoen -- Martinez, Olga I -- Melton, Douglas A -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Apoptosis ; Cell Differentiation ; Cell Line ; Embryo, Mammalian/*cytology ; Humans ; Insulin/*analysis/genetics/immunology/*metabolism ; Islets of Langerhans/*cytology/metabolism ; Mice ; Microscopy, Confocal ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stem Cells/*cytology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Stereochemical course of catalysis by the Tetrahymena ribozyme (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-12
    Description: The group I intron from Tetrahymena catalyzes phosphodiester transfer reactions on various RNA substrates. A modified RNA substrate with a phosphorothioate group in one stereoisomeric form at the site of reaction was synthesized in order to determine the stereochemical course of an RNA-catalyzed reaction. The reaction product was digested with a stereospecific nuclease to determine the configuration of the product phosphorothioate. The reaction occurs with inversion of configuration at phosphorus, implying an in-line pathway for the reaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, J -- Doudna, J A -- Szostak, J W -- New York, N.Y. -- Science. 1989 May 12;244(4905):692-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2470151" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalysis ; DNA-Directed RNA Polymerases/metabolism ; Exons ; Guanosine/metabolism ; Introns ; Molecular Conformation ; Oligonucleotides/metabolism ; Phosphorus ; RNA/chemical synthesis/metabolism ; RNA Precursors/metabolism ; RNA Splicing ; RNA, Catalytic ; RNA, Ribosomal/*metabolism ; Ribonucleases/metabolism ; Structure-Activity Relationship ; T-Phages/enzymology ; Templates, Genetic ; Tetrahymena/*genetics ; Thionucleotides/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-11-22
    Description: Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stenman, Jan M -- Rajagopal, Jay -- Carroll, Thomas J -- Ishibashi, Makoto -- McMahon, Jill -- McMahon, Andrew P -- DK054364/DK/NIDDK NIH HHS/ -- HL076393/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 21;322(5905):1247-50. doi: 10.1126/science.1164594.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19023080" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier/*embryology ; Central Nervous System/*blood supply/*embryology ; Embryonic Induction ; Mice ; Mutation ; *Neovascularization, Physiologic ; Neuroepithelial Cells/physiology ; Proto-Oncogene Proteins/genetics/*physiology ; *Signal Transduction ; Wnt Proteins/genetics/*physiology ; beta Catenin/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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