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  • 1
    Publication Date: 2023-12-21
    Description: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
    Keywords: R5-920 ; RM1-950 ; RC254-282 ; Q1-390 ; toxicity ; cancer treatment ; antineoplastic drugs ; adverse effects ; chemotherapy ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
    Publication Date: 2023-06-20
    Description: Thirty Devonian-Carboniferous Boundary sections of the Rhenish Slate Mountains and adjacent subsurface areas are reviewed with respect to litho-, event, conodont, ammonoid, sequence, and chemostratigraphy. In the interval from the base of the uppermost Famennian (Wocklum Beds, Wocklumian) to the base of the middle Tournaisian (base Lower Alum Shale), 11 conodont and 16 ammonoid (sub)zones are distinguished. The terminology of the Hangenberg Crisis Interval is refined, with an overall regressive Crisis Prelude below the main Hangenberg Extinction, which defines the base of the transgressive Lower Crisis Interval (Hangenberg Black Shale). The glacigenic and regressive Middle Crisis Interval (Hangenberg Shale/Sandstone) is followed by the overall transgressive Upper Crisis Interval that can be subdivided into three parts (I to III) with the help of conodont stratigraphy (upper costatus-kockeli Interregnum = upper ckI, Protognathodus kockeli Zone, and lower part of Siphonodella (Eosiphonodella) sulcata s.l./Pr. kuehni Zone). Protognathodus kockeli includes currently a wide range of forms, which variabilities and precise ranges need to be established before a precise GSSP level should be selected. Returning to its original definition, the former Upper duplicata Zone is re-named as Siphonodella (S.) mehli Zone. It replaces the S. (S.) jii Zone, which is hampered by taxonomic complications. The S. (S.) quadruplicata Zone of Ji (1985) is hardly supported by Rhenish data. The entry of typical S. (S.) lobata (M1) characterises an upper subdivision (subzone) of the S. (S.) sandbergi Zone; the new S. (S.) lobata M2 enters much earlier within the S. (S.) mehli Zone. The ammonoid-defined base of the Wocklum-Stufe (Upper Devonian = UD VI) begins with the Linguaclymenia similis Zone (UD VI-A1). The oldest S. (Eosiphonodella) enter within the Muessenbiaergia bisulcata Zone (UD VI-A2). The traditional Parawocklumeria paradoxa Zone of Schindewolf (1937) is divided into successive P. paprothae (VI-C1), P. paradoxa (VI-C2), and Mayneoceras nucleus (VI-C3) Subzones. In the lower Tournaisian (Lower Carboniferous = LC I), the Gattendorfia subinvoluta Zone is subdivided into G. subinvoluta (LC I-A2) and “Eocanites” nodosus (LC I-A3) Subzones. The Paprothites dorsoplanus Zone (LC I-B) can be divided into Pap. dorsoplanus (LC I-B1) and Paragattendorfia sphaeroides (LC I-B2) Subzones. Potential subdivisions of the Pseudarietites westfalicus (LC I-C) and Parag. patens Zones (LC I-D) are less distinctive. The unfossiliferous or argillaceous upper part of the Hangenberg Limestone and the overlying Lower Alum Shale Event Interval remain regionally unzoned for ammonoids.
    Description: Westfälische Wilhelms-Universität Münster (1056)
    Keywords: ddc:560 ; Rhenish Massif ; Devonian-Carboniferous Boundary ; Lithostratigraphy ; Biostratigraphy ; Hangenberg Crisis ; Carbon isotopes
    Language: English
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  • 3
    Publication Date: 2024-02-23
    Description: 〈title xmlns:mml="http://www.w3.org/1998/Math/MathML"〉ABSTRACT〈/title〉〈p xmlns:mml="http://www.w3.org/1998/Math/MathML" xml:lang="en"〉The study examines bioclastic carbonate contourites that arise from the broad spectrum of bottom‐current related sedimentary processes ranging from deposition to erosion. The result of the intermittent accumulation of sediment are thin and condensed successions with abundant hiatuses. Such bottom‐current deposits are poorly known, since the broadly accepted contourite‐facies model, the bi‐gradational sequence, characterizes environments of contourite depositional systems as a continuous accretion of fine‐grained siliciclastic sediments. To increase current understanding of the carbonate facies within hiatal contourite records, the Eifelian–Frasnian of the Tafilalt Platform in Morocco was investigated. The succession is divided into five facies associations that are interpreted to reflect pelagic sedimentation and deposition from bottom currents on a contourite terrace, a gently inclined section of the upper slope of Gondwana shaped by a water‐mass interface. Contourite deposition was mainly controlled by oxic clear‐water currents (documented by moderately to completely bioturbated limestones with abundant hydrogenetic ferromanganese nodules, and low organic‐carbon contents), at times also by an anoxic water mass (featured by organic‐rich coquinas with absent to sparse bioturbation and predominantly syngenetic framboidal pyrites). Biostratigraphic data and the overall depositional architecture display palaeoceanographic hydrodynamic processes associated with a shifting water‐mass interface. The inner terrace was characterized by an alongslope contourite channel and a small mounded drift at its downslope margin. Energetic bottom currents furthermore caused abraded surfaces, i.e. plain areas of non‐deposition and localized erosion, and sandy condensation layers. The microfacies reflects repeated alternation between suspension deposition, winnowing of fines, bedload traction, dynamic sediment bypassing and reworking, together with concomitant seafloor cementation. Coquinas of mainly planktonic and nektonic organisms are identified as integral parts of bi‐gradational contourite sequences showing inverse and normal grading. Hiatal lag concentrations of carbonate intraclasts, ferromanganese nodules and conodonts often drape hardgrounds and erosional surfaces at the midpoint of these frequently incomplete sequences. This Devonian case provides the opportunity to investigate the spatial and temporal variability of the bed‐scale contourite sequence, also with regard to the drift‐scale depositional architecture. In addition, the identified high‐resolution record is a starting point for unravelling the pattern of oceanic circulation in the Devonian greenhouse world.〈/p〉
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Keywords: ddc:551.7 ; Anti‐Atlas ; bi‐gradational sequence ; bioclastic contourite ; carbonate contourite ; cephalopod limestone ; contourite channel ; contourite terrace
    Language: English
    Type: doc-type:article
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