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  • 1
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    Integration of Optical Coherence Tomography Scan Patterns to Augment Clinical Data Suite (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-19
    Description: Vision changes identified in long duration spaceflight astronauts has led Space Medicine at NASA to adopt a more comprehensive clinical monitoring protocol. Optical Coherence Tomography (OCT) was recently implemented at NASA, including on board the International Space Station in 2013. NASA is collaborating with Heidelberg Engineering to increase the fidelity of the current OCT data set by integrating the traditional circumpapillary OCT image with radial and horizontal block images at the optic nerve head. The retinal nerve fiber layer was segmented by two experienced individuals. Intra-rater (N=4 subjects and 70 images) and inter-rater (N=4 subjects and 221 images) agreement was performed. The results of this analysis and the potential benefits will be presented.
    Keywords: Aerospace Medicine
    Type: JSC-CN-40550 , NASA Human Research Program Investigators'' Workshop (HRP IWS 2018); Jan 22, 2018 - Jan 25, 2018; Galveston, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
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    NASA TECHNICAL REPORTS
  • 2
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    Validation of the NASA Integrated Medical Model: a Space Flight Medical Risk Prediction Tool (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-20
    Description: The Human Research Program funded the development of the Integrated Medical Model (IMM) to quantify the medical component of overall mission risk. The IMM uses Monte Carlo simulation methodology, incorporating space flight and ground medical data, to estimate the probability of mission medical outcomes and resource utilization. To determine the credibility of IMM output, the IMM project team completed two validation studies that compared IMM predicted output to observed medical events from a selection of Shuttle Transportation System (STS) and International Space Station (ISS) missions. The validation study results showed that the IMM underpredicted the occurrence of ~10% of the modeled medical conditions for the STS missions and overpredicted ~20% of the modeled medical conditions for the ISS missions. These findings imply that the strength of IMM predictions to inform decisions depends on simulated mission specifications including length. This discrepancy could result from medical recording differences between ISS and STS that possibly influence observed incidence rates, IMM combining all "mission type" data as constant occurrence rate or fixed proportion across both mission types, misspecification of symptoms to conditions, and gaps in the literature informing the model. Some of these issues will be alleviated by updating the IMM source data through incorporation of the observed validation data.
    Keywords: Aerospace Medicine
    Type: GRC-E-DAA-TN60336 , Probabilistic Safety Assessment and Management (PSAM 14); Sep 16, 2018 - Sep 21, 2018; Los Angeles, CA; United States
    Format: application/pdf
    Location Call Number Expected Availability
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    NASA TECHNICAL REPORTS
  • 3
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    Informal Statistics Help Desk (2017)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: Back by popular demand, the JSC Biostatistics Laboratory and LSAH statisticians are offering an opportunity to discuss your statistical challenges and needs. Take the opportunity to meet the individuals offering expert statistical support to the JSC community. Join us for an informal conversation about any questions you may have encountered with issues of experimental design, analysis, or data visualization. Get answers to common questions about sample size, repeated measures, statistical assumptions, missing data, multiple testing, time-to-event data, and when to trust the results of your analyses.
    Keywords: Statistics and Probability
    Type: JSC-CN-37884 , 2017 Human Research Program Investigators'' Workshop (HRP IWS); Jan 23, 2017 - Jan 26, 2017; Galveston, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
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    NASA TECHNICAL REPORTS
  • 4
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    Comparison of the Integrated Medical Model Predictions to Real World ISS and STS Observations (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Human Research Program funded the development of the integrated medical model (IMM) to quantify the medical component of overall mission risk. The IMM uses Monte Carlo methodology to integrate space flight and ground medical data to assess the probability of mission medical outcomes and resource utilization. To determine the credibility of IMM output the IMM project team completed two validation studies that compare IMM output to observed medical events from a selection of Shuttle Transportation System (STS) and International Space Station (ISS) missions.
    Keywords: Life Sciences (General); Aerospace Medicine
    Type: GRC-E-DAA-TN51425 , 2018 NASA Human Research Program Investigators'' Workshop; Jan 22, 2018 - Jan 25, 2018; Galveston , TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
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