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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Environmental sciences. ; Physics. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Environmental Physics.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Engineering View of Soft Rocks -- Chapter 3. The Geology of Soft Rocks -- Chapter 4. Mudrocks as Soft Rocks -- Chapter 5. Sandstones in Dam Foundations and Tunnels -- Chapter 6. Geomechanical Characterization of Evaporitic Rocks -- Chapter 7. Site Investigation for Soft Rock Mass -- Chapter 8. Geomechanical Properties of Soft Rock Masses by Laboratory and In Situ Testing -- Chapter 9. Interaction Between Water and Soft Rocks -- Chapter 10. Weathering, Erosion, and Susceptibility to Weathering -- Chapter 11. Weathering Of Rocks In Brazil -- Chapter 12. Degradation Processes In Civil Engineering Slopes In Soft Rocks -- Chapter 13. Mining Slopes In Weathered And Weak Rocks -- Chapter 14. Correlation of Properties of Soft Rocks -- Chapter 15. Deformation mechanism of soft rock -- Chapter 16. Soft Rock Roadway Reinforcement -- Chapter 17.Large Deformation Support For Soft Rocks Engineering -- Chapter 18. Rock Mass Classification Of Chalk Marl In The Uk Channel Tunnels Using Q -- Chapter 19. Applications Of The Gsi System To The Classification Of Soft Rocks -- Chapter 20. Soft Rocks In Underground Hydroelectric Schemes -- Chapter 21. Tunneling In Weak Rock -- Chapter 22. Face Stability Of Tunnels In Soft Rocks -- Chapter 23. Characterization Of Soft Rocks In Brazilian Coal Beds -- Chapter 24. Soft Rocks In Dam Foundation And Dam Sites -- Chapter 25. Soft Rock As A Dam Construction Material. .
    Abstract: This book offers a practical reference guide to soft rock mechanics for engineers and scientists. Written by recognized experts, it will benefit professionals, contractors, academics, researchers and students working on rock engineering projects in the fields of civil engineering, mining and construction engineering. Soft Rock Mechanics and Engineering covers a specific subject of great relevance in Rock Mechanics – and one that is directly connected to the design of geotechnical structures under difficult ground conditions. The book addresses practical issues related to the geomechanical properties of these types of rock masses and their characterization, while also discussing advances regarding in situ investigation, safety, and monitoring of geotechnical structures in soft rocks. Lastly, it presents important case histories involving tunnelling, dam foundations, coal and open pit mines and landslides.
    Type of Medium: Online Resource
    Pages: X, 757 p. 521 illus., 371 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030294779
    DDC: 624.151
    Language: English
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  • 2
    Publication Date: 2020-03-19
    Description: Recent discoveries on the neurobiology of the immunocompetent cells of the central nervous system (CNS), microglia, have been recognized as a growing field of investigation on the interactions between the brain and the immune system. Several environmental contexts such as stress, lesions, infectious diseases, and nutritional and hormonal disorders can interfere with CNS homeostasis, directly impacting microglial physiology. Despite many encouraging discoveries in this field, there are still some controversies that raise issues to be discussed, especially regarding the relationship between the microglial phenotype assumed in distinct contexts and respective consequences in different neurobiological processes, such as disorders of brain development and neuroplasticity. Also, there is an increasing interest in discussing microglial–immune system cross-talk in health and in pathological conditions. In this review, we discuss recent literature concerning microglial function during development and homeostasis. In addition, we explore the contribution of microglia to synaptic disorders mediated by different neuroinflammatory outcomes during pre- and postnatal development, with long-term consequences impacting on the risk and vulnerability to the emergence of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 563 (1989), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2014-11-15
    Description: Author(s): Elmar P. Biernat, M. T. Peña, J. E. Ribeiro, Alfred Stadler, and Franz Gross The π-π scattering amplitude calculated with a model for the quark-antiquark interaction in the framework of the covariant spectator theory (CST) is shown to satisfy the Adler zero constraint imposed by chiral symmetry. The CST formalism is established in Minkowski space and our calculations are per... [Phys. Rev. D 90, 096008] Published Fri Nov 14, 2014
    Keywords: Field Theory, General Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 5
    Publication Date: 2014-11-11
    Description: beta-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice beta-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide beta-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis--as a beta-catenin target gene that mediates resilience. Small RNA profiling after excising beta-catenin from nucleus accumbens in the context of chronic stress reveals beta-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish beta-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dias, Caroline -- Feng, Jian -- Sun, Haosheng -- Shao, Ning Yi -- Mazei-Robison, Michelle S -- Damez-Werno, Diane -- Scobie, Kimberly -- Bagot, Rosemary -- LaBonte, Benoit -- Ribeiro, Efrain -- Liu, XiaoChuan -- Kennedy, Pamela -- Vialou, Vincent -- Ferguson, Deveroux -- Pena, Catherine -- Calipari, Erin S -- Koo, Ja Wook -- Mouzon, Ezekiell -- Ghose, Subroto -- Tamminga, Carol -- Neve, Rachael -- Shen, Li -- Nestler, Eric J -- P50 MH096890/MH/NIMH NIH HHS/ -- R00 MH094405/MH/NIMH NIH HHS/ -- England -- Nature. 2014 Dec 4;516(7529):51-5. doi: 10.1038/nature13976. Epub 2014 Nov 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. ; Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA. ; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25383518" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics ; Animals ; DEAD-box RNA Helicases/*genetics/metabolism ; Depression/physiopathology ; Gene Expression Profiling ; *Gene Expression Regulation ; Genome-Wide Association Study ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/*genetics/metabolism ; Neurons/metabolism ; *Resilience, Psychological ; Ribonuclease III/*genetics/metabolism ; Signal Transduction ; Stress, Physiological/*genetics ; beta Catenin/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2014-09-17
    Print ISSN: 0032-079X
    Electronic ISSN: 1573-5036
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Springer
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  • 7
  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 7836-7843 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present here a detailed study of photomodulated transmission and reflectivity at room and liquid-nitrogen temperatures of a series of InxGa1−xAs/GaAs superlattices and a single quantum well. Our samples span a variety of alloy compositions and quantum-well widths. We compare the results of our measurements with the predictions of an envelope-function calculation, which includes wave-vector dependence of the minibands. This comparison allows identification of several spectral features unmistakably arising from miniband dispersion. Also, accurate determination is made of the band-offset parameter, whose value is discussed in the context of those obtained by other authors.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 462-466 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An analytic calculation of the neoclassical fluxes in the plateau regime in the absence of momentum and energy sources is carried out with a general model field, B=B0[1+∑iεi cos(liθ−miζ)], following the moment-equation approach. It is shown that the radial particle and heat fluxes resulting from each harmonic (εi) are additive and have the same sign. Consequently, the neoclassical fluxes in a stellarator in the plateau regime are larger than those in the corresponding "equivalent'' tokamak (same aspect ratio and rotational transform). Numerical calculations performed with a drift kinetic equation solver agree to within 10% with the analytic results for the examples considered.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 7994-7998 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We studied the low temperature (77 K) photomodulated reflection and transmission as well as the photoluminescence at 2.2 K of a self-assembled InxGa1−xAs quantum dot layer grown on a (100) GaAs substrate in the vicinity of a two-dimensional electron gas. The dot layer was grown without rotation of the substrate in order to achieve a gradual variation of the In concentration along the wafer diameter. This resulted in an increase in the density of quantum dots along the In concentration gradient, which is reflected in a characteristic dependence of the relative intensities of the spectral lines. A consistent assignment of the optical structure observed in all spectra leads to an estimate of the average value of the Fermi energy in the conduction band of the wetting layer (EF(similar, equals)13.4 meV). The variation of this Fermi energy along the composition gradient can be obtained from the spectra, and an estimate of the gradient of the density of quantum dots along this direction can be made. A careful comparison of the variation of the critical energy of the different lines suggests that the average quantum dot size depends on the In molar fraction of the alloy, which is seen to vary more or less linearly across the wafer diameter. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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