ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
  • 1
    Publication Date: 2016-11-02
    Description: Human major depressive disorder (MDD), along with related mood disorders, is among the world’s greatest public health concerns; however, its pathophysiology remains poorly understood. Persistent changes in gene expression are known to promote physiological aberrations implicated in MDD. More recently, histone mechanisms affecting cell type- and regional-specific chromatin structures have...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2016-07-08
    Description: This study examines genomic prediction within 8416 Mexican landrace accessions and 2403 Iranian landrace accessions stored in gene banks. The Mexican and Iranian collections were evaluated in separate field trials, including an optimum environment for several traits, and in two separate environments (drought, D and heat, H) for the highly heritable traits, days to heading (DTH), and days to maturity (DTM). Analyses accounting and not accounting for population structure were performed. Genomic prediction models include genotype environment interaction (G E). Two alternative prediction strategies were studied: (1) random cross-validation of the data in 20% training (TRN) and 80% testing (TST) (TRN20-TST80) sets, and (2) two types of core sets, "diversity" and "prediction", including 10% and 20%, respectively, of the total collections. Accounting for population structure decreased prediction accuracy by 15–20% as compared to prediction accuracy obtained when not accounting for population structure. Accounting for population structure gave prediction accuracies for traits evaluated in one environment for TRN20-TST80 that ranged from 0.407 to 0.677 for Mexican landraces, and from 0.166 to 0.662 for Iranian landraces. Prediction accuracy of the 20% diversity core set was similar to accuracies obtained for TRN20-TST80, ranging from 0.412 to 0.654 for Mexican landraces, and from 0.182 to 0.647 for Iranian landraces. The predictive core set gave similar prediction accuracy as the diversity core set for Mexican collections, but slightly lower for Iranian collections. Prediction accuracy when incorporating G E for DTH and DTM for Mexican landraces for TRN20-TST80 was around 0.60, which is greater than without the G E term. For Iranian landraces, accuracies were 0.55 for the G E model with TRN20-TST80. Results show promising prediction accuracies for potential use in germplasm enhancement and rapid introgression of exotic germplasm into elite materials.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2015-07-18
    Description: We analyse whether a stellar atmosphere model computed with the code cmfgen provides an optimal description of the stellar observations of WR 136 and simultaneously reproduces the nebular observations of NGC 6888, such as the ionization degree, which is modelled with the pycloudy code. All the observational material available (far- and near-UV and optical spectra) was used to constrain such models. We found that even when the stellar luminosity and the mass-loss rate were well constrained, the stellar temperature T * at  = 20 can be in a range between 70 000 and 110 000 K. When using the nebula as an additional restriction, we found that the stellar models with T *  ~ 70 000 K represent the best solution for both, the star and the nebula. Results from the photoionization model show that if we consider a chemically homogeneous nebula, the observed N + /O + ratios found in different nebular zones can be reproduced; therefore, it is not necessary to assume a chemical inhomogeneous nebula. Our work shows the importance of calculating coherent models including stellar and nebular constraints. This allowed us to determine, in a consistent way, all the physical parameters of both the star and its associated nebula. The chemical abundances derived are 12 + log(N/H) = 9.95, 12 + log(C/H) = 7.84 and 12 + log(O/H) = 8.76 for the star and 12 + log(N/H) = 8.40, 12 + log(C/H) = 8.86 and 12 + log(O/H) = 8.20 for the nebula. Thus, the star and the nebula are largely N- and C-enriched and O-depleted.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2016-02-26
    Description: Determination of saturated hydraulic conductivity, K s , and the shape parameters α and n of the water retention curve, θ(h), is of paramount importance to characterize the water flow in the vadose zone. This work presents a modified upward infiltration method to estimate K s , α and n from numerical inverse analysis of the measured cumulative upward infiltration (CUI) at multiple constant tension lower boundary conditions. Using the HYDRUS-2D software, a theoretical analysis on a synthetic loam soil under different soil tensions (0, 0-10, 0-50, and 0-100 cm), with and without an overpressure step of 10 cm high form the top boundary condition at the end of the upward infiltration process, was performed to check the uniqueness and the accuracy of the solutions. Using a tension sorptivimeter device, the method was validated in a laboratory experiment on five different soils: a coarse and a fine sand, and a 1-mm sieved loam, clay loam and silt-gypseous soils. The estimated α and n parameters were compared to the corresponding values measured with the TDR-pressure cell method. The theoretical analysis demonstrates that K s and θ(h) can be simultaneously estimated from measured upward cumulative infiltration when high (〉50 cm) soil tensions are initially applied at the lower boundary. Alternatively, satisfactory results can be also obtained when medium tensions (〈50 cm) and the K s calculated from the overpressure step at the end of the experiment are considered. A consistent relationship was found between the α (R 2  = 0.86, p 〈 0.02) and n (R 2  = 0.97, p 〈 0.001) values measured with the TDR-pressure cell and the corresponding values estimated with the tension soptivimeter. The error between the α (in logarithm scale) and n values estimated with the inverse analysis and the corresponding values measured with pressure chamber were 3.1 and 6.1%, respectively. This article is protected by copyright. All rights reserved.
    Print ISSN: 0885-6087
    Electronic ISSN: 1099-1085
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2015-12-10
    Description: : BigBWA is a new tool that uses the Big Data technology Hadoop to boost the performance of the Burrows–Wheeler aligner (BWA). Important reductions in the execution times were observed when using this tool. In addition, BigBWA is fault tolerant and it does not require any modification of the original BWA source code. Availability and implementation: BigBWA is available at the project GitHub repository: https://github.com/citiususc/BigBWA Contact: josemanuel.abuin@usc.es Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2011-04-06
    Description: Understanding oceanic processes, both physical and biological, that control atmospheric CO2 is vital for predicting their influence during the past and into the future. The Eastern Equatorial Pacific (EEP) is thought to have exerted a strong control over glacial/interglacial CO2 variations through its link to circulation and nutrient-related changes in the Southern Ocean, the primary region of the world oceans where CO2-enriched deep water is upwelled to the surface ocean and comes into contact with the atmosphere. Here we present a multiproxy record of surface ocean productivity, dust inputs, and thermocline conditions for the EEP over the last 40,000 y. This allows us to detect changes in phytoplankton productivity and composition associated with increases in equatorial upwelling intensity and influence of Si-rich waters of sub-Antarctic origin. Our evidence indicates that diatoms outcompeted coccolithophores at times when the influence of Si-rich Southern Ocean intermediate waters was greatest. This shift from calcareous to noncalcareous phytoplankton would cause a lowering in atmospheric CO2 through a reduced carbonate pump, as hypothesized by the Silicic Acid Leakage Hypothesis. However, this change does not seem to have been crucial in controlling atmospheric CO2, as it took place during the deglaciation, when atmospheric CO2 concentrations had already started to rise. Instead, the concomitant intensification of Antarctic upwelling brought large quantities of deep CO2-rich waters to the ocean surface. This process very likely dominated any biologically mediated CO2 sequestration and probably accounts for most of the deglacial rise in atmospheric CO2.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2011-03-16
    Description: Author(s): F. Bernardoni, N. Garron, P. Hernández, S. Necco, and C. Pena We report on our first experiences with a mixed action setup with overlap valence quarks and nonperturbatively O(a) improved Wilson sea quarks. For the latter we employ CLS N_{f} =2 configurations with light sea-quark masses at small lattice spacings. Exact chiral symmetry allows to consider very li... [Phys. Rev. D 83, 054503] Published Tue Mar 15, 2011
    Keywords: D1
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2014-07-01
    Description: Nuclear fuel bundles include spacers essentially for mechanical stability and to influence the flow dynamics and heat transfer phenomena along the fuel rods. This work presents the analysis of the turbulence effects of a split-type and swirl-type spacer-grid geometries on single phase in a PWR (pressurized water reactor) rod bundle. Various computational fluid dynamics (CFD) calculations have been performed and the results validated with the experiments of the OECD/NEA-KAERI rod bundle CFD blind benchmark exercise on turbulent mixing in a rod bundle with spacers at the MATiS-H facility. Simulation of turbulent phenomena downstream of the spacer-grid presents high complexity issues; a wide range of length scales are present in the domain increasing the difficulty of defining in detail the transient nature of turbulent flow with ordinary turbulence models. This paper contains a complete description of the procedure to obtain a validated CFD model for the simulation of the spacer-grids. Calculations were performed with the commercial code ANSYS CFX using large eddy simulation (LES) turbulence model and the CFD modeling procedure validated by comparison with measurements to determine their suitability in the prediction of the turbulence phenomena.
    Print ISSN: 1687-6075
    Electronic ISSN: 1687-6083
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    American Physical Society (APS)
    Publication Date: 2014-11-12
    Description: Author(s): E. Endress and C. Pena We study the dependence on the charm quark mass of the leading-order low-energy constants of the ΔS=1 effective Hamiltonian, with the aim of elucidating the role of the charm mass scale in the ΔI=1/2 rule for K→ππ decay. To that purpose, finite-volume chiral perturbation theory predictions are match... [Phys. Rev. D 90, 094504] Published Tue Nov 11, 2014
    Keywords: Lattice Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2014-11-11
    Description: beta-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice beta-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide beta-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis--as a beta-catenin target gene that mediates resilience. Small RNA profiling after excising beta-catenin from nucleus accumbens in the context of chronic stress reveals beta-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish beta-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257892/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dias, Caroline -- Feng, Jian -- Sun, Haosheng -- Shao, Ning Yi -- Mazei-Robison, Michelle S -- Damez-Werno, Diane -- Scobie, Kimberly -- Bagot, Rosemary -- LaBonte, Benoit -- Ribeiro, Efrain -- Liu, XiaoChuan -- Kennedy, Pamela -- Vialou, Vincent -- Ferguson, Deveroux -- Pena, Catherine -- Calipari, Erin S -- Koo, Ja Wook -- Mouzon, Ezekiell -- Ghose, Subroto -- Tamminga, Carol -- Neve, Rachael -- Shen, Li -- Nestler, Eric J -- P50 MH096890/MH/NIMH NIH HHS/ -- R00 MH094405/MH/NIMH NIH HHS/ -- England -- Nature. 2014 Dec 4;516(7529):51-5. doi: 10.1038/nature13976. Epub 2014 Nov 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. ; Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA. ; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25383518" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics ; Animals ; DEAD-box RNA Helicases/*genetics/metabolism ; Depression/physiopathology ; Gene Expression Profiling ; *Gene Expression Regulation ; Genome-Wide Association Study ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/*genetics/metabolism ; Neurons/metabolism ; *Resilience, Psychological ; Ribonuclease III/*genetics/metabolism ; Signal Transduction ; Stress, Physiological/*genetics ; beta Catenin/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...