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  • 1
    Electronic Resource
    Electronic Resource
    The design and evaluation of a virtual distributed computing environment (1998)
    Springer
    Cluster computing 1 (1998), S. 81-93 
    Details
    ISSN: 1573-7543
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Current advances in high-speed networks such as ATM and fiber-optics, and software technologies such as the JAVA programming language and WWW tools, have made network-based computing a cost-effective, high-performance distributed computing environment. Metacomputing, a special subset of network-based computing, is a well-integrated execution environment derived by combining diverse and distributed resources such as MPPs, workstations, mass storage, and databases that show a heterogeneous nature in terms of hardware, software, and organization. In this paper we present the Virtual Distributed Computing Environment (VDCE), a metacomputing environment currently being developed at Syracuse University. VDCE provides an efficient web-based approach for developing, evaluating, and visualizing large-scale distributed applications that are based on predefined task libraries on diverse platforms. The VDCE task libraries relieve end-users of tedious task implementations and also support reusability. The VDCE software architecture is described in terms of three modules: (a) the Application Editor, a user-friendly application development environment that generates the Application Flow Graph (AFG) of an application; (b) the Application Scheduler, which provides an efficient task-to-resource mapping of AFG; and (c) the VDCE Runtime System, which is responsible for running and managing application execution and for monitoring the VDCE resources. We present experimental results of an application execution on the VDCE prototype for evaluating the performance of different machine and network configurations. We also show how the VDCE can be used as a problem-solving environment on which large-scale, network-centric applications can be developed by a novice programmer rather than by an expert in low-level details of parallel programming languages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019069012307
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    Paper (German National Licenses)
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  • 2
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    Sustainability, Vol. 7, Pages 5773-5792: A Review of China’s Rural Water Management (2015)
    MDPI Publishing
    Details
    Publication Date: 2015-05-09
    Description: With less than 6% of total global water resources but one fifth of the global population, China is facing serious challenges for its water resources management, particularly in rural areas due to the long-standing urban-rural dualistic structure and the economic-centralized developmental policies. This paper addresses the key water crises in rural China including potable water supply, wastewater treatment and disposal, water for agricultural purposes, and environmental concerns, and then analyzes the administrative system on water resources from the perspective of characteristics of the current administrative system and regulations; finally, synthetic approaches to solve water problems in rural China are proposed with regard to institutional reform, regulation revision, economic instruments, technology innovation and capacity-building. These recommendations provide valuable insights to water managers in rural China so that they can identify the most appropriate pathways for optimizing their water resources, reducing the total wastewater discharge and improving their water-related ecosystem.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 3
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    UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer (2014)
    Springer Nature
    Details
    Publication Date: 2014-11-08
    Description: Cyclins are essential for cell proliferation, the cell cycle and tumorigenesis in all eukaryotes. UbcH10 regulates the degradation of cyclins in a ubiquitin-dependent manner. Here, we report that UbcH10 is likely involved in tumorigenesis. We found that cancer cells exposed to n-acetyl-leu-leu-norleucinal (ALLN) treatment and UbcH10 depletion exhibit a synergistic therapeutic effect. Abundant expression of UbcH10 drives resistance to ALLN-induced cell death, while cells deficient in UbcH10 were susceptible to ALLN-induced cell death. The depletion of UbcH10 hindered tumorigenesis both in vitro and in vivo, as assessed by colony formation, growth curve, soft agar and xenograft assays. These phenotypes were efficiently rescued through the introduction of recombinant UbcH10. In the UbcH10-deficient cells, alterations in the expression of cyclins led to cell cycle changes and subsequently decreases in tumorigenesis. The tumorigenesis of xenograft tumors from UbcH10-deficient cells treated with ALLN was decreased relative to wild-type cells treated with ALLN in nude mice. On the molecular level, we observed that UbcH10 deficiency enhances the activation of caspase 8 and caspase 3 but not caspase 9 to impair cell viability upon ALLN treatment. Collectively, our results suggest that, as an oncogene, UbcH10 is a potential drug target for the treatment of colorectal cancer. Scientific Reports 4 doi: 10.1038/srep06910
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 4
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    Sustainability, Vol. 8, Pages 222: The Decoupling of Resource Consumption and Environmental Impact from Economic Growth in China: Spatial Pattern and Temporal Trend (2016)
    MDPI Publishing
    Details
    Publication Date: 2016-03-01
    Description: Unprecedented economic achievement in China has occurred along with rising resource consumption and waste productions levels. The goal of sustainability requires the decoupling of economic growth from resource consumption (resource decoupling) and environmental degradation (impact decoupling). For this paper, the performances of resource decoupling (energy and water) and impact decoupling (wastewater, SO2 and CO2) in China were evaluated, and the spatial pattern and temporal trend of decoupling performance were investigated by using the rescaled range analysis (R/S). The results indicate the following. (1) The performance of resource decoupling during the investigated period is worse than that of traditional impact (SO2 and wastewater) decoupling, but better than that of the CO2 emission. Additionally, the decoupling performances of energy consumption and related pollutant emission (except CO2) are better than that of water usage and wastewater discharge; (2) The decoupling performance of energy consumption, SO2 and CO2, has substantially improved from the 10th Five-Year Planning Period (FYP) (2001–2005) to the 11th FYP (2006–2010), which indicates that the decoupling performance is highly related the environmental policy; (3) The spatial disparities of the performance of resource and impact decoupling are declining, which indicates the existence of cross-province convergence in decoupling performance; (4) The decoupling performance of SO2 and water usage in most of regions shows an improving trend. Inversely, the decoupling performance of energy consumption, CO2 emission, and wastewater discharge in most regions show a decreasing trend; (5) China needs more stringent water-saving targets and wastewater discharge standards; better policy efforts to improve the water recycling level both in agricultural, industrial and municipal level are required to prevent the decreasing trend of the decoupling performance.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 5
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    Promoter-associated RNAs and promoter-targeted RNAs (2012)
    Springer
    Details
    Publication Date: 2012-03-14
    Print ISSN: 1420-682X
    Electronic ISSN: 1420-9071
    Topics: Biology , Medicine
    Published by Springer
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  • 6
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    Sustainability, Vol. 6, Pages 8967-8979: Environmental Legislation in China: Achievements, Challenges and Trends (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-12-06
    Description: Compared to the environmental legislation of many developed countries, China’s environmental legislation was initiated late, beginning in 1979, but nevertheless has obtained considerable achievements. As many as thirty environmental laws have provided rules regarding prevention and control of pollution, resource utilization, and ecological protection in China. However, China’s environmental legislation still faces a series of challenges and problems, including that the sustainable development concept has not yet been fully implemented, as well as presence of gaps and non-coordination phenomena between laws and regulations, unclear responsibility, imperfect system design, imbalance between rights and obligations, higher impacts resulted from the GDP-centralized economy, lack of operability and instruments in the legal content, as well as difficulty of public participation. In contrast, China’s environmental legislation has improved, as a result of learning from experience in developed countries and introducing innovations stimulated by domestic environmental pressure. Looking into the future, increased attention to environmental protection and ecological consciousness paid by China’s new leaders will bring a valuable opportunity to China’s further development concerning environmental legislation. In the future, there are prospects for the gradual improvement of legal approaches, continuous improvements of legislation to mitigate environmental problems, and more opportunities to strengthen public participation can be predicted.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 7
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    Sustainability, Vol. 7, Pages 3714-3720: Sustainability in China: Bridging Global Knowledge with Local Action (2015)
    MDPI Publishing
    Details
    Publication Date: 2015-03-31
    Description: As the biggest emerging and developing country, and the second largest economy on the planet, China’s road to sustainability has attracted global attention; therefore, we need to have a deeper understanding to address this issue at very different levels. This editorial mainly reviews the contributions of the published papers in the Special Issue of “Sustainability in China: Bridging Global Knowledge with Local Action”, the main findings in this special edition suggest that the concept of sustainability is more comprehensive and complex, and the transformation process from scientific knowledge to local action still has a long way to go, not only in China, but also in many developing countries. More research on the fundamental and innovative processes of sustainable transformations should be conducted. China needs to make more efforts to strengthen its road to sustainability, by merging all relevant types of knowledge, both within and outside science, as well as locally and globally.As the biggest emerging and developing country, and the second largest economy on the planet, China's road to sustainability has attracted global attention; therefore, we need to have a deeper understanding to address this issue at very different levels. This editorial mainly reviews the contributions of the published papers in the Special Issue of "Sustainability in China: Bridging Global Knowledge with Local Action", the main findings in this special edition suggest that the concept of sustainability is more comprehensive and complex, and the transformation process from scientific knowledge to local action still has a long way to go, not only in China, but also in many developing countries. More research on the fundamental and innovative processes of sustainable transformations should be conducted. China needs to make more efforts to strengthen its road to sustainability, by merging all relevant types of knowledge, both within and outside science, as well as locally and globally.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 8
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    China's uncertain CO2 emissions (2012)
    Springer Nature
    Details
    Publication Date: 2012-10-27
    Description: Nature Climate Change 2 762 doi: 10.1038/nclimate1715
    Print ISSN: 1758-678X
    Electronic ISSN: 1758-6798
    Topics: Geosciences
    Published by Springer Nature
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  • 9
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    Sub-10 fs spectroscopy of K-TCNQ crystal for observation of intramolecular vibration modulation in melting of the Peierls dimer (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-08-15
    Description: Author(s): Kazuaki Nakata, Eiji Tokunaga, Juan Du, Bing Xue, Jun Miyazaki, Keisuke Seto, and Takayoshi Kobayashi K-TCNQ crystals show photoinduced phase transition (PIPT) between a Mott insulator and a spin Peierls (SP) phase, having Tc=395 K (= and the crystal has Tc=395 K of the PIPT). We report the intra-molecular vibrations in the excited K-TCNQ crystal after impulsive excitation using a sub 9.4 fs pulse l... [Phys. Rev. B 90, 085119] Published Thu Aug 14, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Caged Glutamates with π-Extended 1,2-Dihydronaphthalene Chromophore: Design, Synthesis, Two-Photon Absorption Property, and Photochemical Reactivity (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-08-15
    Description: The Journal of Organic Chemistry DOI: 10.1021/jo501425p
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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