ISSN:
1573-9023
Keywords:
Drug-receptor docking
;
3D database searching
;
De novo drug design
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Many approaches have been developed for solving the ‘docking problem’: Predict the structure and binding free energy of a ligand-receptor complex given only the structures of the free ligand and receptor. We review major approaches for docking small-molecule ligands to receptors and focus on the successes and limitations of their application to drug design.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02174531
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